The project
BioFusion at a glance
Addressing Advanced HealthCare Materials call
- Advanced material-based regenerative approach for degenerative spinal disorders that improves patient’s quality of life and reduces the human and economic burden of these conditions.
- Bioresorbable ceramic-based cage with osteoinductive and load-bearing properties, as well as antiinflammatory potential that enables complete and lifelong vertebral fusion.
- Focus on entire value chain to address an unmet medical need: a one-shot treatment for life.
- Involvement of relevant stakeholders: researchers, clinicians, industry and patients, equally and fairly distributed from Brazil and the Netherlands sides.
- Strengthen Brazil and the Netherlands position in Regenerative Medicine and giving both countriesbased industry a pole position in the field.
The project in numbers
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2 Countries
5 Years
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7 Number of WPs
Gender Balance
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??? Industrial partners
Impacts
BioFusion societal impact is based on the following assumptions:
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Complete bone healing between adjacent vertebrae after spinal fusion will restore overall spine health. This increase in pain-free mobility together with reducing comorbidities related to autologous bone harvesting will improve QoL.
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BioFusion will be a life-long treatment, eliminating the direct treatment costs of spinal fusion revision surgeries and autologous bone harvesting, as well as indirectly reducing costs related to absenteeism and loss of productivity, ultimately leading to a reduction of healthcare costs.
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Fully regenerative spine fusion cages will be safe and well-accepted, leading to the creation of a novel commercial sector within spinal disorders treatment, and both Brazil and the Netherlands will be willing to invest in and accommodate this sector.
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Multidisciplinary trained students and researchers will be better suited to meet the scientific needs of the emerging BioFusion market than their monodisciplinary counterparts.
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By bringing together complementary disciplines and talented researchers from both countries, BioFusion will achieve a leading knowledge position in Advanced Healthcare Materials.
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BioFusion findings have the potential to be extend to a broad range of biomedical applications in the long term.
Project structure
Principal Investigators (PI)
Dr. Miguel Dias Castilho
Development of design & fabrication technologies that enable the local control of (bio) material composition and structure across multiple length scales is fundamental to understand complex regenerative processes in the human body; as well as to develop approaches for functional restoration of damaged&diseased tissues and organs. To address this challenge, Castilho team uses a material-by-design approach, combining advanced 3D printing technologies and computational design, to develop instructive materials for regenerative medicine, particularly of musculoskeletal tissues, like bone. Castilho’s research is interdisciplinary, bringing together engineers, materials scientists and cell biologists. An important focus area of the team is on exploring opportunities for translation of instructive materials in human clinics.
Miguel Castilho is an Associate Professor of Biomaterials design and processing at TU/e. He holds a MSc degree in Mechanical Engineering and a PhD in Biomedical engineering (cum laude) from the University of Lisbon (IST, Portugal). During his PhD studies he was a visiting researcher at Department for Functional Materials in Medicine and Dentistry, University of Würzburg (Germany), focusing on engineering Bioactive inorganic materials and bone bioengineering. From 2015 - 2018, he was a post-doctoral research fellow in Biofabrication at the University Medical Center Utrecht (UMC Utrecht, The Netherlands). In 2018, he become an Assistant professor at UMC Utrecht and at the Regenerative Medicine Center (The Netherlands), a role he held until 2021. In 2021, he started a tenured position as an Assistant Professor in the Department of Biomedical Engineering at TU/e, while maintaining an adjunct appointment in Biofabrication at UMC Utrecht. In 2024, he was appointed Associate Professor
PhD Ana Paula Rosifini Alves
Brazilian side of the consortium
PhD Alberto Cliquet Jr
PhD Pedro Xavier Rodriguez Massaguer
Juliana Regina Peiró
Juliana has a degree in Veterinary Medicine, from São Paulo State University Júlio de Mesquita Filho, UNESP, Brazil, has specialization in the Faculty of Agricultural and Veterinary Sciences Jaboticabal from UNESP.
She has Master and PhD degree from São Paulo State University Júlio de Mesquita Filho, UNESP, in Veterinary Surgery area, with the titles Experimental endotoxemia in horses: clinical-laboratory evaluation for Master and Intraperitoneal Injection of Lipopolysaccharide (LPS) in Horses for PhD. She completed the post-doctorate in Equine Medicine at the Equine Health Studies Program at Louisiana State University.
She was Coordinator of the Postgraduate Program in Animal Science and Deputy Coordinator of the Postgraduate Program in Animal Science. Currently is Adjunct professor at the Faculty of Veterinary Medicine (Araçatuba Campus) UNESP.
Pedro is a researcher at the Renato Archer Information Technology Center, located at the Laboratory of Three-Dimensional Technologies (LAprint) of the Division of Technologies for Production and Health (DITPS), where he has participated in the coordination of projects with the Ministry of Health and Petrobrás.
He obtained his bachelor's, master's, and doctorate degrees in Mechanical Engineering from the State University of Campinas. His undergraduate thesis was on the Solid Modeling of Femur Prosthesis. During his master's and doctorate studies, he worked in development of technological products aimed at human health.
Currently, he coordinates the bioengineering group of the Laboratory of Three-Dimensional Technologies of the CTI and is the head of DITPS. He has experience in mechanical engineering, with an emphasis on bioengineering and stress analysis, working mainly on the following topics: finite elements, bioengineering, three-dimensional stress analysis, and BioCAD geometric modeling.
Bruno Giuliatti Winter
Bruno has a bachelor's degree in Biomedical Engineering from National Institute of Telecommunications INATEL, Brazil, having an interest in areas related to medical equipment, biomaterials, anatomy and physics of the human body.
He is currently a PhD student in Materials Engineering in the Postgraduate Program in Engineering – UNESP (Guaratinguetá), whose focus of research is scaffolds/cages to substitute the intervertebral discs that have problems in order to minimize or to finish the back pain.
Jasmine Keise de Oliveira Silva
Jasmine holds a degree in Materials Engineering from the Faculty of Engineering of Guaratinguetá - FEG/UNESP. During her undergraduate studies, she discovered her passion for biomaterials and began studying the surface treatment of biodegradable iron-based alloys.
She is currently a PhD student in Materials Science in the Postgraduate Program in Materials Science at (FEIS) - UNESP, where she studies the development of sustainable and biofunctional calcium phosphate-based nanoparticles produced from eggshell waste for incorporation into metal surfaces to promote bone regeneration.
Dutch side of the consortium
Dr. Zeinab Niloofar Tahmasebi Birganiv
Dr. Pamela Habibović
Prof. dr. Pamela Habibović (1977) is Professor of Inorganic Biomaterials at Maastricht University. Since February 2022, she holds the position of Rector Magnificus of Maastricht University. Pamela was a founding partner of MERLN Institute for Technology-Inspired Regenerative Medicine, established in 2014, and Chair of MERLN’s Department for Instructive Biomaterials Engineering. Between 2019 and 2022, she was the Scientific Director of MERLN.
Initially trained as a chemical engineer, in 2005, Pamela obtained a PhD degree from the University of Twente, the Netherlands on the topic of materials for biomedical applications. Following postdoctoral research at Children’s Hospital Boston and McGill University, in 2008, she started her research group at the University of Twente. In 2014, she moved to Maastricht University. The main focus of her research is on synthetic bone graft substitutes, bioinorganics, nanomaterials for theranostics in regenerative medicine and high-throughput approaches in biomaterials research. For her research she received prestigious Veni, Vidi, Aspasia and Gravitation grants of the Dutch Research Council NWO, among other external research funds.
Pamela Habibović served as the President of the European Society for Biomaterials between 2017 and 2021 and as an Associate Editor of the RSC journal Biomaterials Science between 2019 and 2022. In 2017, she received the Jean Leray Award of the European Society for Biomaterials and in 2021 she was elected a Fellow of the Royal Society of Chemistry. She has published over 100 peer-review articles on the topic of biomaterials and regenerative medicin
PhD Paul Willems
Orthopaedic Surgeon, Maastricht UMC+, Professor of Integrated Spinal Care, Maastricht University.
Paul Willems studied medicine at the Catholic Univeristeit Nijmegen in 2002, he round his studies. In 2011 he was promoted in the field of "Decision making in the surgical treatment of chronic low back pain. The performance of prognostic test to select a patient 'for lumbar spinal fusion.
After completing his education, he attended AO Spine Surgery Fellowship at St. Maartens in Nijmegen. From 2004-2007 he was a staff member in the partnership of the Orthopedics Surgery-VieCuri Medical Center in Venlo. He is a staff member Orthopedics in MUMC + since September 2007. His specialization concerns in particular the spine. Besides, he is project leader of the Spin Center Maastricht.
In addition to his clinical work, he is involved in the education of students in Medical Engineering TU Eindhoven and the AKO students MUMC +.
Florence Barrère-de Groot has a PhD in a biomimetic materials for bone regeneration and over 20 years professional experience. She leads the development of new products for bone repair at Kuros Biosciences BV. Graduated in Biomaterial Sciences, her interests lie in the creation and market authorization of innovative devices for clinical use. Her relevant experience includes:
- Leading projects for the commercialization of submicron surface structured implantable medical devices for 10 years
- Development of new products formulation, patent, GMP manufacturing process; biocompatibility, sterilization, coordination of preclinical and clinical studies.
- Market approval for clinical use in EU and USA (CE mark, 510k clearance).
- Experience in preclinical and clinical trials, bone graft products for the spine, orthopaedic, dental and craniomaxillofacial use
- Patenting, Intellectual Protection, Freedom to Operate and PCT application of methods and products
- Co-authorship of more than 25 journal papers on bone grafting materials, book chapters and a number of conference publications
Dr Claire Villette
Claire’s main research focuses on the interactions between cancerous metastases and bone intrinsic remodelling processes, with a particular interest in the influence of mechanical loading. Her work relies on a dual in-silico / in-vitro approach, harnessing the synergy between mechanistic computational modelling and experimental tissue engineering. After her undergraduate and MSc degrees in Maths and Physics in France (Ecole Nationale Superieure des Mines de Saint-Etienne), Claire specialised in numerical methods for biomedical engineering through a master degree in the UK (Imperial College London). She conducted her PhD studies at Imperial College London on ‘Structural Meso and Microscale Finite-Element-Based Methods for the Prediction of Bone Architecture and Failure’ (2012-2016). In 2018, after a postdoctoral project on optimisation of bone tissue engineering scaffolds, Claire joined Oxford-based CRO Physiomics, specialised in computational modelling of cancer therapies for Pharma and Biotech R&D. In 2022, she was awarded an FWO senior post-doctoral fellowship to join Prof. Liesbet Geris’ team in KU Leuven and investigate the therapeutic potential of mechanical loading on bone metastases.
Research interests:
- Mechanobiology
- Bone remodelling
- Biomechanics
- Cancer treatments (primary and metastases)
- In-silico modelling (agent-based, finite element)
- In-vitro disease models
Aline Fragas Gouveia
Eindhoven University of Technology – TU/e, Department of Biomedical Engineering.
Aline Fragas Gouveia is a researcher with a strong interest in biomechanics and computational modelling. She completed both her Bachelor's and Master's degrees in Biomedical Engineering in the University of Lisbon with a focus on biomechanics and medical devices. Her master's thesis revolved around the development of a finite element model of the spine and the biomechanical analysis of a novel interspinous posterior device in cases of degenerative disc disease.
Aline is currently pursuing her PhD at TU Eindhoven as part of the BioFusion project. Her aim will be to design, fabricate, and characterize a subject-specific cage implant that promotes spinal fusion through mechanical stimulation while providing adequate mechanical strength until complete vertebrae fusion
Dr Bert van Rietbergen
Bert van Rietbergen is an Associate Professor in the Orthopaedic Biomechanics research group. Most of his research is aimed at the evaluation of bone structural and mechanical properties for the study of bone diseases (osteoporosis) and implant failure. He has developed a new computational approach for mechanical analysis of bone structures from high-resolution images, and over the last decade his work has focused on clinical applications of this approach for improved diagnosis of bone fracture risk.
Apart from bone fracture risk diagnosis, it is also important to predict how this fracture risk may develop as the results of aging, pharmacological treatments or orthopedic surgery. Van Rietbergen aims at predicting this by developing computational models based on mechanical and biological principles that are validated relative to data obtained from clinical studies.
In recent projects Van Rietbergen is concerned with patient specific prognosis of the risk of bone fracture, multiscale approaches to predict bone remodeling, the analysis of surgical procedures such as used for correction/stabilization of skeletal deformities/fractures and the application of biomaterials.
Beatrice Francesca Massel
Beatrice Francesca Massel is a passionate researcher with a strong background in Biomedical Engineering and a keen interest in advancing Regenerative Medicine. She earned her bachelor’s and master’s degrees in Biomedical Engineering from Polytechnic of Turin, where she discovered her enthusiasm for biomaterials and Tissue Engineering. Her master's thesis involved the development of innovative 2D and 3D substrates designed to improve the interaction between cells and biomaterials in in vitro models of skeletal muscle tissue, sparking her dedication to creating solutions that can make a real difference in patients' lives.
Currently, Beatrice is undertaking her doctoral research as part of the BioFusion project in MERLN Institute for Technology-Inspired Regenerative Medicine at Maastricht University. Her work focuses on designing a calcium phosphate-based biomaterial that not only supports bone growth but also integrates seamlessly with the body to improve outcomes for patients. She is excited to contribute to a project that bridges cutting-edge material science with impactful healthcare solutions.
Collaboration between FAPESP and NWO