Skip to main content

The project

BioFusion at a glance

Addressing Advanced HealthCare Materials call

  • Advanced material-based regenerative approach for degenerative spinal disorders that improves patient’s quality of life and reduces the human and economic burden of these conditions.
  • Bioresorbable ceramic-based cage with osteoinductive and load-bearing properties, as well as antiinflammatory potential that enables complete and lifelong vertebral fusion.
  • Focus on entire value chain to address an unmet medical need: a one-shot treatment for life.
  • Involvement of relevant stakeholders: researchers, clinicians, industry and patients, equally and fairly distributed from Brazil and the Netherlands sides.
  • Strengthen Brazil and the Netherlands position in Regenerative Medicine and giving both countriesbased industry a pole position in the field.

The project in numbers

??? Partners

2 Countries

5 Years

2024-2029

??? Funding

7 Number of WPs

Gender Balance

M 60% F 40%

??? Clinical partners

??? Research partners

??? Industrial partners

Impacts

BioFusion societal impact is based on the following assumptions:

  • Complete bone healing between adjacent vertebrae after spinal fusion will restore overall spine health. This increase in pain-free mobility together with reducing comorbidities related to autologous bone harvesting will improve QoL.
  • BioFusion will be a life-long treatment, eliminating the direct treatment costs of spinal fusion revision surgeries and autologous bone harvesting, as well as indirectly reducing costs related to absenteeism and loss of productivity, ultimately leading to a reduction of healthcare costs.
  • Fully regenerative spine fusion cages will be safe and well-accepted, leading to the creation of a novel commercial sector within spinal disorders treatment, and both Brazil and the Netherlands will be willing to invest in and accommodate this sector.
  • Multidisciplinary trained students and researchers will be better suited to meet the scientific needs of the emerging BioFusion market than their monodisciplinary counterparts.
  • By bringing together complementary disciplines and talented researchers from both countries, BioFusion will achieve a leading knowledge position in Advanced Healthcare Materials.
  • BioFusion findings have the potential to be extend to a broad range of biomedical applications in the long term.

Project structure

Principal Investigators (PI)

Dr. Miguel Dias Castilho

Eindhoven University of Technology – TU/e, Department of Biomedical Engineering.

PhD Ana Paula Rosifini Alves

Universidade Estadual Paulista - UNESP, School of Engineering, Guaratinguetá Campus.

Brazilian side of the consortium

Co-applicant

PhD Alberto Cliquet Jr

Universidade Estadual de Campinas - UNICAMP, Faculty of Medical Sciences.
Collaboration partner

PhD Pedro Xavier Rodriguez Massaguer

Co-founder 3D Biotechnology Solutions - 3DBS, Campinas-SP. Business Development & Innovation Solutions in Biofabrication and Tissue Engineering | Bio-printing | Electrospinning | Organs on a Chip | In vitro models
Collaboration partner

Juliana Regina Peiró

Universidade Estadual Paulista - UNESP, Faculty of Veterinary Medicine, Araçatuba Campus
Collaboration partner

Pedro Yoshito Noritomi

Centro de Tecnologia da Informação Renato Archer – Campinas-SP
PhD candidate

Bruno Giuliatti Winter

Universidade Estadual Paulista - UNESP, School of Engineering, Guaratinguetá Campus
PhD candidate

Jasmine Keise de Oliveira Silva

Universidade Estadual Paulista - UNESP, School of Engineering, Guaratinguetá Campus

Dutch side of the consortium

Co-applicant

Dr. Zeinab Niloofar Tahmasebi Birganiv

MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University
Dr. Zeinab Niloofar Tahmasebi Birganiv
MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University
Dr. Niloofar Tahmasebi Birgani is an assistant professor at the MERLN Institute for Technology-Inspired Regenerative Medicine at Maastricht University with expertise in biomaterials field, with particular interest in biomaterial design, characterization, and application in engineering and regeneration of bone and bone-to-soft tissue interfaces. She earned her Master’s degree in Biomedical Engineering with a focus on biomaterials and later completed her PhD in Tissue Regeneration Department at the University of Twente, the Netherlands. Her doctoral work explored calcium phosphate-based biomaterials enriched with inorganic additives to enhance bone regeneration, emphasizing osteogenic differentiation and vascularization. In 2018, Niloofar embarked on a post-doctoral journey at the MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University. Her work there focused on 3D biological screening platforms for biomaterials, microbiomaterials, and the bottom-up engineering of musculoskeletal tissues. Currently, Niloofar’s research encompasses the development of advanced micro-scale biomaterials and their use in bottom-up tissue engineering to develop novel regenerative therapies and in vitro miniaturized models, with a particular focus on musculoskeletal tissues.
Co-applicant

Dr. Pamela Habibović

MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University
Dr. Pamela Habibović
MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University

Prof. dr. Pamela Habibović (1977) is Professor of Inorganic Biomaterials at Maastricht University. Since February 2022, she holds the position of Rector Magnificus of Maastricht University. Pamela was a founding partner of MERLN Institute for Technology-Inspired Regenerative Medicine, established in 2014, and Chair of MERLN’s Department for Instructive Biomaterials Engineering. Between 2019 and 2022, she was the Scientific Director of MERLN.

Initially trained as a chemical engineer, in 2005, Pamela obtained a PhD degree from the University of Twente, the Netherlands on the topic of materials for biomedical applications. Following postdoctoral research at Children’s Hospital Boston and McGill University, in 2008, she started her research group at the University of Twente. In 2014, she moved to Maastricht University. The main focus of her research is on synthetic bone graft substitutes, bioinorganics, nanomaterials for theranostics in regenerative medicine and high-throughput approaches in biomaterials research. For her research she received prestigious Veni, Vidi, Aspasia and Gravitation grants of the Dutch Research Council NWO, among other external research funds.

Pamela Habibović served as the President of the European Society for Biomaterials between 2017 and 2021 and as an Associate Editor of the RSC journal Biomaterials Science between 2019 and 2022. In 2017, she received the Jean Leray Award of the European Society for Biomaterials and in 2021 she was elected a Fellow of the Royal Society of Chemistry. She has published over 100 peer-review articles on the topic of biomaterials and regenerative medicin

Co-applicant

PhD Paul Willems

Orthopaedic Surgeon, Maastricht UMC+, Professor of Integrated Spinal Care, Maastricht University.

PhD Paul Willems
Orthopaedic Surgeon, Maastricht UMC+, Professor of Integrated Spinal Care, Maastricht University.

Paul Willems studied medicine at the Catholic Univeristeit Nijmegen in 2002, he round his studies. In 2011 he was promoted in the field of "Decision making in the surgical treatment of chronic low back pain. The performance of prognostic test to select a patient 'for lumbar spinal fusion.

After completing his education, he attended AO Spine Surgery Fellowship at St. Maartens in Nijmegen. From 2004-2007 he was a staff member in the partnership of the Orthopedics Surgery-VieCuri Medical Center in Venlo. He is a staff member Orthopedics in MUMC + since September 2007. His specialization concerns in particular the spine. Besides, he is project leader of the Spin Center Maastricht.

In addition to his clinical work, he is involved in the education of students in Medical Engineering TU Eindhoven and the AKO students MUMC +.

Collaboration partner

PhD Florence de Groot

Vice President R&D at Kuros Biosciences BV, Bilthoven, Utrecht, NL.

PhD Florence de Groot
Vice President R&D at Kuros Biosciences BV, Bilthoven, Utrecht, NL.

Florence Barrère-de Groot has a PhD in a biomimetic materials for bone regeneration and over 20 years professional experience. She leads the development of new products for bone repair at Kuros Biosciences BV. Graduated in Biomaterial Sciences, her interests lie in the creation and market authorization of innovative devices for clinical use. Her relevant experience includes:

  • Leading projects for the commercialization of submicron surface structured implantable medical devices for 10 years
  • Development of new products formulation, patent, GMP manufacturing process; biocompatibility, sterilization, coordination of preclinical and clinical studies.
  • Market approval for clinical use in EU and USA (CE mark, 510k clearance).
  • Experience in preclinical and clinical trials, bone graft products for the spine, orthopaedic, dental and craniomaxillofacial use
  • Patenting, Intellectual Protection, Freedom to Operate and PCT application of methods and products
  • Co-authorship of more than 25 journal papers on bone grafting materials, book chapters and a number of conference publications
Collaboration partner

Dr Claire Villette

FWO senior postdoctoral research fellow at KU Leuven, Belgium Department of Development and Regeneration Skeletal Biology and Engineering Claire Villette - Biomechanics Research Unit
Dr Claire Villette
FWO senior postdoctoral research fellow at KU Leuven, Belgium Department of Development and Regeneration Skeletal Biology and Engineering Claire Villette - Biomechanics Research Unit

Claire’s main research focuses on the interactions between cancerous metastases and bone intrinsic remodelling processes, with a particular interest in the influence of mechanical loading.  Her work relies on a dual in-silico / in-vitro approach, harnessing the synergy between mechanistic computational modelling and experimental tissue engineering. After her undergraduate and MSc degrees in Maths and Physics in France (Ecole Nationale Superieure des Mines de Saint-Etienne), Claire specialised in numerical methods for biomedical engineering through a master degree in the UK (Imperial College London). She conducted her PhD studies at Imperial College London on ‘Structural Meso and Microscale Finite-Element-Based Methods for the Prediction of Bone Architecture and Failure’ (2012-2016). In 2018, after a postdoctoral project on optimisation of bone tissue engineering scaffolds, Claire joined Oxford-based CRO Physiomics, specialised in computational modelling of cancer therapies for Pharma and Biotech R&D. In 2022, she was awarded an FWO senior post-doctoral fellowship to join Prof. Liesbet Geris’ team in KU Leuven and investigate the therapeutic potential of mechanical loading on bone metastases. 

Research interests:

  • Mechanobiology
  • Bone remodelling
  • Biomechanics
  • Cancer treatments (primary and metastases)
  • In-silico modelling (agent-based, finite element)
  • In-vitro disease models
PhD candidate

Aline Fragas Gouveia

Eindhoven University of Technology – TU/e, Department of Biomedical Engineering.

Collaboration partner

Dr Bert van Rietbergen

Associate Professor Eindhoven University of Technology – TU/e, Department of Biomedical Engineering.
Collaboration partner

Beatrice Francesca Massel

MERLN Institute for Technology-Inspired Regenerative Medicine Maastricht University
Beatrice Francesca Massel
MERLN Institute for Technology-Inspired Regenerative Medicine Maastricht Universit

Beatrice Francesca Massel is a passionate researcher with a strong background in Biomedical Engineering and a keen interest in advancing Regenerative Medicine. She earned her bachelor’s and master’s degrees in Biomedical Engineering from Polytechnic of Turin, where she discovered her enthusiasm for biomaterials and Tissue Engineering. Her master's thesis involved the development of innovative 2D and 3D substrates designed to improve the interaction between cells and biomaterials in in vitro models of skeletal muscle tissue, sparking her dedication to creating solutions that can make a real difference in patients' lives.
Currently, Beatrice is undertaking her doctoral research as part of the BioFusion project in MERLN Institute for Technology-Inspired Regenerative Medicine at Maastricht University. Her work focuses on designing a calcium phosphate-based biomaterial that not only supports bone growth but also integrates seamlessly with the body to improve outcomes for patients. She is excited to contribute to a project that bridges cutting-edge material science with impactful healthcare solutions.

Collaboration between FAPESP and NWO

This programme falls under the Merian Fund, The Netherlands, cooperation São Paulo Research Foundation FAPESP, Brazil. This bilateral collaboration is a fund for international scientific cooperation. It aims to further stimulate joint, impactoriented research by Dutch and Brazilian researchers.